Revision de los mejores articulos del 2011

Information sourced from Journal Watch:

General Medicine Year in Review 2011

The most important medical topics of 2011, as chosen by the editors of Journal Watch General Medicine

Each year, the editors of Journal Watch General Medicine choose the year’s most important thematic areas in clinical research. We try to strike a balance between relevance to primary care, recognition of landmark studies, and media publicity and public awareness. Some of our stories emerge from one important study, and others come from several studies on a single topic. The order of these stories is not intended to reflect their relative importance.


USPSTF Recommends Against Prostate Cancer Screening [NEJM Perspective 2011 Nov 24;365(21). Medline ® abstract | Free full-text NEJM article PDF]

Screening for Lung Cancer: Radiography? No. Low-Dose CT? Maybe. [Reduced lung-cancer mortality with low-dose computed tomographic screening. Free full-text NEJM article PDF | No mortality benefit with annual x-ray screening for lung cancer. JAMAabstract | Complications are common after transthoracic lung biopsy. Ann Intern Med Medline ® abstract]

Ovarian Cancer Screening: No Effect on Mortality [Effect of screening on ovarian cancer mortality: The Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Randomized Controlled Trial. Free full-text JAMA article PDF]

New Hepatitis C Drugs Improve Genotype 1 Response Rates [Boceprevir for untreated chronic HCV genotype 1 infection. Free full-text NEJM article PDF | Boceprevir for previously treated chronic HCV genotype 1 infection. Free full-text NEJM article PDF | Telaprevir for previously untreated chronic hepatitis C virus infection. Free full-text NEJM article PDF | Telaprevir for retreatment of HCV infection. Free full-text NEJM article PDF]

Risk Stratification for CAD: What’s Worth Doing? [Associations between C-reactive protein, coronary artery calcium, and cardiovascular events: implications for the JUPITER population. Lancetabstract | Heart Protection Study Collaborative Group. C-reactive protein concentration and the vascular benefits of statin therapy. Lancetabstract | Impact of coronary computed tomographic angiography results on patient and physician behavior in a low-risk population. Arch Intern Medabstract]

Aspirin for Preventing Colorectal Cancers and Other Solid Tumors [Long-term effect of aspirin on colorectal cancer incidence and mortality. Lancetabstract | Effect of daily aspirin on long-term risk of death due to cancer: Lancetabstract]

Selective and Nonselective NSAIDs Are Associated with Excess Cardiovascular Risk [Duration of treatment with nonsteroidal anti-inflammatory drugs and impact on risk of death and recurrent myocardial infarction in patients with prior myocardial infarction. Free full-text Circulation article PDF | Non-steroidal anti-inflammatory drug use and risk of atrial fibrillation or flutter. Free full-text BMJ article PDF]

Atypical Femur Fractures with Bisphosphonates [Bisphosphonate use and the risk of subtrochanteric or femoral shaft fractures in older women. Free full-text JAMA article PDF | Bisphosphonate use and atypical fractures of the femoral shaft. Free full-text NEJM article PDF]

Supplementation with Niacin or [Omega]-3 Fatty Acids Is Ineffective for Secondary Prevention [Niacin in patients with low HDL cholesterol levels receiving intensive statin therapy. NEJMabstract | Effects of B vitamins and omega 3 fatty acids on cardiovascular diseases. Free full-text BMJ article PDF | n €“3 fatty acids and cardiovascular events after myocardial infarction. Free full-text NEJM article PDF]

Which Strategies Are Best for Measuring BP and Diagnosing Hypertension? [Measuring blood pressure for decision making and quality reporting: Where and how many measures? Free full-text Ann Int Med article PDF | Conventional versus automated measurement of blood pressure in primary care patients with systolic hypertension. Free full-text BMJ article PDF | Relative effectiveness of clinic and home blood pressure monitoring compared with ambulatory blood pressure monitoring in diagnosis of hypertension. Free full-text BMJ article PDF | Cost-effectiveness of options for the diagnosis of high blood pressure in primary care: A modelling study. Lancetabstract]

Intermittent Budesonide in Preschool Children with Recurrent Wheezing [Daily or intermittent budesonide in preschool children with recurrent wheezing. NEJM Medline ® abstract | Daily versus as-needed corticosteroids for mild persistent asthma. Free full-text NEJM article PDF | Use of beclomethasone dipropionate as rescue treatment for children with mild persistent asthma (TREXA). Lancetabstract | Free 2007 NAEP Expert Panel Report 3 Asthma Guidelines PDF]

Three More Topics That Drew Our Attention in 2011
[Tiotropium versus salmeterol for the prevention of exacerbations of COPD. Free full-text NEJM article PDF | Comparison of inhaled long-acting β-agonist and anticholinergic effectiveness in older patients with chronic obstructive pulmonary disease. Free full-text Ann Int Med article PDF]

[Coronary-artery bypass surgery in patients with left ventricular dysfunction. Free full-text NEJM article PDF]

[Herpes zoster vaccine in older adults and the risk of subsequent herpes zoster disease. Free full-text JAMA article PDF | Herpes zoster recurrences more frequent than previously reported. Free full-text Mayo Clinic Proceedings article PDF]

€” Allan S. Brett, MD, Editor-in-Chief, and the JW General Medicine Associate Editors

Published in Journal Watch General Medicine December 29, 2011

Copyright © 2011. Massachusetts Medical Society. All rights reserved.

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