las mejores revisiones de medicina interna del 2015

Information sourced from NEJM Journal Watch:

General Medicine Year in Review 2015

Allan S. Brett, MD

The most important medical topics of 2015, as chosen by the editors of NEJM Journal Watch General Medicine

Each year, the editors of NEJM Journal Watch General Medicine choose the year’s most important thematic areas in clinical research. We try to strike a balance among relevance to primary care, recognition of landmark studies, and acknowledgment of media publicity and public awareness. Some of our stories emerge from one important study, and others come from several studies on a single topic. The order of these stories is not intended to reflect their relative importance.


A New Blood Pressure Target for High-Risk Patients?
[The ACCORD Study Group. Effects of intensive blood-pressure control in type 2 diabetes mellitus. N Engl J Med 2010 Apr 29; 362:1575. Full-text NEJM article PDF in PubMed® Central | PubMed® abstract]

[The SPRINT Research Group. A randomized trial of intensive versus standard blood-pressure control. N Engl J Med 2015 Nov 26; 373:2103. Full-text NEJM article PDF | PubMed® abstract]

[Chobanian AV. Time to reassess blood-pressure goals. N Engl J Med 2015 Nov 26; 373:2093. Full-text NEJM article PDF]

Spironolactone for Resistant Hypertension
[Williams B et al. Spironolactone versus placebo, bisoprolol, and doxazosin to determine the optimal treatment for drug-resistant hypertension (PATHWAY-2): A randomised, double-blind, crossover trial. Lancet 2015 Nov 21; 386:2059. Full-text Lancet article PDF in PubMed® Central | PubMed® abstract]

Endovascular Treatment of Stroke — A Dramatic Reversal
[Berkhemer OA et al. A randomized trial of intraarterial treatment for acute ischemic stroke. N Engl J Med 2015 Jan 1; 372:11. Full-text NEJM article PDF | PubMed® abstract]

[Campbell BCV et al. Endovascular therapy for ischemic stroke with perfusion-imaging selection. N Engl J Med 2015 Mar 12; 372:1009. Full-text NEJM article PDF | PubMed® abstract]

[Goyal M et al. Randomized assessment of rapid endovascular treatment of ischemic stroke. N Engl J Med 2015 Mar 12; 372:1019. Full-text NEJM article PDF | PubMed® abstract]

[Saver JL et al. Stent-retriever thrombectomy after intravenous t-PA vs. t-PA alone in stroke. N Engl J Med 2015 Jun 11; 372:2285. Full-text NEJM article PDF | PubMed® abstract]

[Jovin TG et al. Thrombectomy within 8 hours after symptom onset in ischemic stroke. N Engl J Med 2015 Jun 11; 372:2296. Full-text NEJM article PDF | PubMed® abstract]

[Furlan AJ. Endovascular therapy for stroke — it’s about time. N Engl J Med2015 Jun 11; 372:2347. NEJM editorial preview]

[Powers WJ et al. 2015 AHA/ASA focused update of the 2013 guidelines for the early management of patients with acute ischemic stroke regarding endovascular treatment: A guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke 2015 Jun 29; STR.0000000000000074. Full-text Stroke article PDF]

Cholesterol Guidelines and Statin Therapy: Debate Continues
[DeFilippis AP et al. An analysis of calibration and discrimination among multiple cardiovascular risk scores in a modern multiethnic cohort. Ann Intern Med 2015 Feb 17; 162:266. Full-text Ann Intern Med article PDF in PubMed® Central | PubMed® abstract]

[Pursnani A et al. Guideline-based statin eligibility, coronary artery calcification, and cardiovascular events. JAMA 2015 Jul 14; 314:134. Full-text JAMA article | PubMed® abstract]

[Downs JR and O’Malley PG. Management of dyslipidemia for cardiovascular disease risk reduction: Synopsis of the 2014 U.S. Department of Veterans Affairs and U.S. Department of Defense clinical practice guideline. Ann Intern Med 2015 Aug 18; 163:291. Full-text Ann Intern Med article | PubMed® abstract]

[Cederberg H et al. Increased risk of diabetes with statin treatment is associated with impaired insulin sensitivity and insulin secretion: A 6 year follow-up study of the METSIM cohort. Diabetologia 2015 May; 58:1109. Full-text Diabetologia article | PubMed® abstract]

[Mansi I et al. Statins and new-onset diabetes mellitus and diabetic complications: A retrospective cohort study of US healthy adults. J Gen Intern Med 2015 Nov; 30:1599. PubMed® abstract]

[Besseling J et al. Association between familial hypercholesterolemia and prevalence of type 2 diabetes mellitus. JAMA 2015 Mar 10; 313:1029. Full-text JAMA article | PubMed® abstract]

[Preiss D and Sattar N. Does the LDL receptor play a role in the risk of developing type 2 diabetes? JAMA 2015 Mar 10; 313:1016. JAMA editorial extract]

Corticosteroids for Hospitalized Community-Acquired Pneumonia — Time to Change Practice?
[Torres A et al. Effect of corticosteroids on treatment failure among hospitalized patients with severe community-acquired pneumonia and high inflammatory response: A randomized clinical trial. JAMA 2015 Feb 17; 313:677. Full-text JAMA article | PubMed® abstract]

[Wunderink RG. Corticosteroids for severe community-acquired pneumonia: Not for everyone. JAMA 2015 Feb 17; 313:673. JAMA editorial extract]

[Blum CA et al. Adjunct prednisone therapy for patients with community-acquired pneumonia: A multicentre, double-blind, randomised, placebo-controlled trial. Lancet 2015 Apr 18; 385:1511. PubMed® abstract]

[Annane D. Corticosteroids and pneumonia: Time to change practice. Lancet2015 Apr 18; 385:1484. Lancet abstract]

[Siemieniuk RAC et al. Corticosteroid therapy for patients hospitalized with community-acquired pneumonia: A systematic review and meta-analysis. Ann Intern Med 2015 Oct 6; 163:519. PubMed® abstract]

[Restrepo MI et al. Corticosteroids for severe community-acquired pneumonia: Time to change clinical practice. Ann Intern Med 2015 Oct 6; 163:560. Ann Intern Med editorial preview]

High-Flow Oxygen for Respiratory Support
[Frat J-P et al. High-flow oxygen through nasal cannula in acute hypoxemic respiratory failure. N Engl J Med 2015 Jun 4; 372:2185. Full-text NEJM article PDF | PubMed® abstract]

[Stéphan F et al. High-flow nasal oxygen vs noninvasive positive airway pressure in hypoxemic patients after cardiothoracic surgery: A randomized clinical trial. JAMA 2015 Jun 16; 313:2331. Full-text JAMA article | PubMed® abstract]

Functional or Anatomic Testing for Patients with Chest Pain?
[Douglas PS et al. Outcomes of anatomical versus functional testing for coronary artery disease. N Engl J Med 2015 Apr 2; 372:1291. Full-text NEJM article PDF in PubMed® Central | PubMed® abstract]

[Kramer CM. Cardiovascular imaging and outcomes — PROMISEs to keep. N Engl J Med 2015 Apr 2; 372:1366. NEJM editorial preview]

[SCOT-HEART Investigators. CT coronary angiography in patients with suspected angina due to coronary heart disease (SCOT-HEART): An open-label, parallel-group, multicentre trial. Lancet 2015 Jun 13; 385:2383. Full-text Lancet article PDF | PubMed® abstract]

[Levsky JM et al. Coronary computed tomography angiography versus radionuclide myocardial perfusion imaging in patients with chest pain admitted to telemetry: A randomized trial. Ann Intern Med 2015 Aug 4; 163:174. PubMed® abstract]

Managing Venous Thromboembolism
[Couturaud F et al. Six months vs extended oral anticoagulation after a first episode of pulmonary embolism: The PADIS-PE randomized clinical trial.JAMA 2015 Jul 7; 314:31. Full-text JAMA article | PubMed® abstract]

[Kearon C et al. D-dimer testing to select patients with a first unprovoked venous thromboembolism who can stop anticoagulant therapy: A cohort study. Ann Intern Med 2015 Jan 6; 162:27. PubMed® abstract]

[Mismetti P et al. Effect of a retrievable inferior vena cava filter plus anticoagulation vs anticoagulation alone on risk of recurrent pulmonary embolism: A randomized clinical trial. JAMA 2015 Apr 28; 313:1627. Full-text JAMA article | PubMed® abstract]

[Carrier M et al. Screening for occult cancer in unprovoked venous thromboembolism. N Engl J Med 2015 Aug 20; 373:697. Full-text NEJM article PDF | PubMed® abstract]

Testosterone Supplementation in Older Men with Low Testosterone Levels?
[Basaria S et al. Effects of testosterone administration for 3 years on subclinical atherosclerosis progression in older men with low or low-normal testosterone levels: A randomized clinical trial. JAMA 2015 Aug 11; 314:570.PubMed® abstract]

[Gianatti EJ et al. Effect of testosterone treatment on constitutional and sexual symptoms in men with type 2 diabetes in a randomized, placebo-controlled clinical trial. J Clin Endocrinol Metab 2014 Oct; 99:3821. Full-text J Clin Endocrinol Metab article | PubMed® abstract]

Increasing Calcium Intake Has Minimal Effects on Bone-Mineral Density and Fracture Risk
[Tai V et al. Calcium intake and bone mineral density: Systematic review and meta-analysis. BMJ 2015 Sep 29; 351:h4183. Full-text BMJ article PDF |PubMed® abstract]

[Bolland MJ et al. Calcium intake and risk of fracture: Systematic review. BMJ2015 Sep 29; 351:h4580. Full-text BMJ article | PubMed® abstract]

[Bolland MJ et al. Calcium supplements with or without vitamin D and risk of cardiovascular events: Reanalysis of the Women’s Health Initiative limited access dataset and meta-analysis. BMJ 2011 Apr 19; 342:d2040. Full-text BMJ article in PubMed® Central PubMed® abstract]

ART for All
[Okulicz JF et al. Influence of the timing of antiretroviral therapy on the potential for normalization of immune status in human immunodeficiency virus 1–infected individuals. JAMA Intern Med 2015 Jan; 175:88. Full-text JAMA Intern Med article PDF in PubMed® Central | PubMed® abstract]

[Schacker TW et al. Defining success with antiretroviral therapy. JAMA Intern Med 2015 Jan; 175:99. JAMA Intern Med editorial preview]

[The INSIGHT START Study Group. Initiation of antiretroviral therapy in early asymptomatic HIV infection. N Engl J Med 2015 Aug 27; 373:795. Full-text NEJM article PDF | PubMed® abstract]

Infant Exposure Might Limit Later Peanut Allergies
[Du Toit G et al. Randomized trial of peanut consumption in infants at risk for peanut allergy. N Engl J Med 2015 Feb 26; 372:803. Full-text NEJM article PDF in PubMed® Central | PubMed® abstract]

[Gruchalla RS and Sampson HA. Preventing peanut allergy through early consumption — ready for prime time? N Engl J Med 2015 Feb 26; 372:875.Full-text NEJM editorial PDF]

[Fleischer DM et al. Consensus communication on early peanut introduction and the prevention of peanut allergy in high-risk infants. Pediatrics 2015 Sep; 136:600. Full-text Pediatrics article]

NEJM Journal Watch is produced by NEJM Group, a division of the Massachusetts Medical Society. Copyright ©2016 Massachusetts Medical Society. All rights reserved.

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