Malaria is transmitted by female Anopheles mosquito that usually bites from dusk to dawn which are infected by protozoan parasites species of Plasmodium genus. There are 4 types of Plasmodium which are Plasmodium falciparum, P. vivax, P. ovale and P. malariae. In addition, P. knowlesi, a parasite of Old World (Eastern Hemisphere) monkeys, has been identified in South East Asia[1,2]. Estimation by The World Health Organization (WHO) of reported cases from Indonesia were 2.5 million in 2006. Papua (300,000) and East Nusa Tenggara (70,000) provinces were the highest provincesofclinicalmalariacases,annually.Basedonthe 2011 World Malaria Report, in 2010, 4.3 million malaria cases were reported, of which 2.4 million were parasitolo gically con firmed .